cocoa butter / Phenylephrine Rectal Suppository

Brand(s)
Hemorrodil, Preparation H Suppositories Reformulated Oct 2013
Category(s)
otc
SPL Type(s)
Human OTC
Master SPL
Better Living Brands Llc (2015-11-05)
Oldest Current Product
1964-03-01
License(s)
OTC MONOGRAPH FINAL
RxNORM
RECTAL SUPPOSITORY\COCOA BUTTER:PHENYLEPHRINE
SPL Active
RECTAL\SUPPOSITORY\COCOA BUTTER: PHENYLEPHRINE HYDROCHLORIDE
SPL Moiety
RECTAL\SUPPOSITORY\COCOA BUTTER: PHENYLEPHRINE

product(s) by strength(s)

cocoa butter 0.854 mg/mg / phenylephrine hydrochloride 0.0025 mg/mg rectal suppository

product(s)(s)

#idcategorylabelerfirst marketedactive ingredient(s)routedose formspl
1001130160OTC MONOGRAPH FINALL. Perrigo Company2012-12-26COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY6f85e72b-b323-4e1f-973c-5ced01564988
2003630160OTC MONOGRAPH FINALWalgreens2012-09-29COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYd0fb0c36-dc29-455b-81fd-9b5792161f39
3118220160OTC MONOGRAPH FINALRite Aid2013-01-31COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY7f93a84b-d32f-4a12-9fe6-850bb09c6207
4211300160OTC MONOGRAPH FINALBetter Living Brands Llc2012-11-13COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY00c4cf75-0be7-46bb-8855-1e2ec1dae8dd
5370120160OTC MONOGRAPH FINALShopko Stores Operating Co, Llc2013-08-06COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY50f66c5a-7776-49d5-99cc-91e431682c55
6378080160OTC MONOGRAPH FINALH-E-B2012-11-11COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYe62b741c-1c1f-4bac-809a-3c315c12c276
7411630557OTC MONOGRAPH FINALSupervalu, Inc2013-02-16COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY13a7f88b-be9e-4cd8-89ed-169bddf7b041
8411900160OTC MONOGRAPH FINALWakefern Food Corporation2013-09-05COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY4583b50f-d864-41e1-803b-6ca44f6799d5
9412500330OTC MONOGRAPH FINALMeijer Distribution, Inc2013-01-16COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYbff8f495-6007-4206-aaf3-7c08a0721b91
10415200160OTC MONOGRAPH FINALFoodhold U.S.A., Llc2013-01-02COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY68413266-83fd-4960-9380-10280c9afd44
11425070160OTC MONOGRAPH FINALHy-Vee2013-03-11COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY57a271a7-04f5-4c98-8259-894bbde7fbfb
12490350160OTC MONOGRAPH FINALWalmart2012-09-04COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY1f6b907a-6bc3-4ef8-9973-d36339501686
13497380313OTC MONOGRAPH FINALKmart Corp2013-04-06COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY96df6b3d-9a71-42ee-b205-c70df5828cbc
14553120557OTC MONOGRAPH FINALWestern Family2012-11-02COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYecc0e2b3-3d48-4634-827b-24f5c0b7cfa1
15553160160OTC MONOGRAPH FINALDza Brands,2012-10-31COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY37db02e2-7710-4753-b90b-ffc690452644
16553190160OTC MONOGRAPH FINALFamily Dollar (Family Wellness)2012-12-05COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY3effe95a-2d1d-471e-a9e2-368bac232662
17559100160OTC MONOGRAPH FINALDolgencorp, Llc2012-10-04COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY6be1896d-f247-48d0-8a2f-f9b0d8e4a36e
18560620160OTC MONOGRAPH FINALPublix Super Markets, Inc2012-12-20COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYa8b1f7e9-78cf-4631-9375-938d5abb0fda

cocoa butter 0.855 mg/mg / phenylephrine hydrochloride 0.0025 mg/mg rectal suppository

product(s)(s)

#idcategorylabelerfirst marketedactive ingredient(s)routedose formspl
1116730395OTC MONOGRAPH FINALTarget Corp2011-07-01COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY21744505-0fbc-4e74-bd8f-e1ae5e322f9f
2118220450OTC MONOGRAPH FINALRite Aid2011-07-01COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYcfb1d1d9-d45d-4ead-bd73-48456dcff3df
3541620045OTC MONOGRAPH FINALGeritrex Corp2012-02-29COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY52e27a92-93e4-4941-b1b3-9de03b5a39c6
4584010102OTC MONOGRAPH FINALAditya Labs Inc2014-09-03COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY217c6442-f88f-4fb0-bda9-d585fc807aa6
5597790401OTC MONOGRAPH FINALCvs2011-07-01COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY79aba427-9500-4689-a2a3-c8128eb08398

cocoa butter 0.884 mg/mg / phenylephrine hydrochloride 0.0025 mg/mg rectal suppository

product(s)(s)

#idbrandcategorylabelerfirst marketedactive ingredient(s)routedose formspl
1001130279OTC MONOGRAPH FINALL. Perrigo Company2014-09-04COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY379f8738-a871-4b09-abd1-c86386dfee04
2003630279OTC MONOGRAPH FINALWalgreens2014-09-26COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYe511d184-aedd-46f7-ab90-d7724766df73
3005732880Preparation H Suppositories Reformulated Oct 2013OTC MONOGRAPH FINALPfizer Consumer Healthcare2004-01-05COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYa23ded81-78ba-c199-a8f0-aaf360b216ff
4005732883Preparation H Suppositories Reformulated Oct 2013OTC MONOGRAPH FINALPfizer Consumer Healthcare2004-01-05COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYa23ded81-78ba-c199-a8f0-aaf360b216ff
5116730279OTC MONOGRAPH FINALTarget Corp2014-05-23COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYd56ecdfd-5c77-41e0-a42c-d135d9f0a817
6118220005OTC MONOGRAPH FINALRite Aid2015-01-09COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYddafbdca-32c2-49c1-83d3-35b4155958c9
7211300279OTC MONOGRAPH FINALBetter Living Brands Llc2014-10-07COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY56a1ce72-8e54-4eb2-9c6e-eb479e7633a1
8211300628OTC MONOGRAPH FINALBetter Living Brands Llc2015-11-03COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYe74b71a1-915d-4e5b-b548-d5cce7945dbd
9301420279OTC MONOGRAPH FINALKroger2014-08-23COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYd44ca22a-dc20-454d-99aa-403a8c7a3e00
10368000279OTC MONOGRAPH FINALTop Care (Topco Associates Llc)2014-11-03COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY81a3546b-5099-4b9a-b774-b3e79316b267
11370120279OTC MONOGRAPH FINALShopko Stores Operating Co, Llc2014-10-29COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYaadcdc22-d47a-469d-bfb2-953c01dc13fa
12378080279OTC MONOGRAPH FINALH-E-B2014-09-30COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY1435432d-5ff2-468b-808d-fb0c99a0717b
13411630279OTC MONOGRAPH FINALSupervalu, Inc2014-09-05COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYd29b7824-ff9e-4875-b3de-92721c8add0e
14412500279OTC MONOGRAPH FINALMeijer Distribution, Inc2014-10-08COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY1431397e-3515-4794-a494-70667948e14c
15415200004OTC MONOGRAPH FINALFoodhold U.S.A., Llc2014-12-21COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYea5d26ad-2bfd-4178-857d-ce6b243cd760
16425070279OTC MONOGRAPH FINALHy-Vee2015-03-28COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYbf1beca0-cc9b-4100-9db7-77f2d1e5497c
17490350463OTC MONOGRAPH FINALWalmart2014-05-23COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY581dd76f-d052-4448-8139-9a2e31891b25
18497380279OTC MONOGRAPH FINALKmart Corp2014-10-02COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY3eb7905a-f6a0-47e7-b233-2f2a193c7706
19553120279OTC MONOGRAPH FINALWestern Family2014-10-02COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY714528a3-30d7-449b-8360-1587be91bb3d
20553160279OTC MONOGRAPH FINALDza Brands,2014-10-30COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYea78ee9b-46c9-4c10-99e3-0b40652e659d
21553190279OTC MONOGRAPH FINALFamily Dollar (Family Wellness)2014-10-29COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY970a6043-7302-4642-b33b-0f2502d85a24
22559100279OTC MONOGRAPH FINALDolgencorp, Llc2014-08-28COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY0415c51b-5a12-49d4-8968-0131ddb85545
23560620279OTC MONOGRAPH FINALPublix Super Markets, Inc2014-09-08COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYa241cb37-7007-4fd8-a12e-f3fc6d6f780e
24597790279OTC MONOGRAPH FINALCvs2014-09-11COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYe8a8431b-7851-4da0-a4fa-e242cf3daf2e
25613570135HemorrodilOTC MONOGRAPH FINALZurich Medical Labs, Llc1964-03-01COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY1c704359-89a4-449c-961c-ad527cb467c2
26638680208OTC MONOGRAPH FINALQuality Choice (Chain Drug Marketing Association)2007-09-26COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYa01ee29d-02ca-4473-aa90-c2e8174dba26
27680160321OTC MONOGRAPH FINALChain Drug Consortium, Llc2015-03-25COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORY8638a48e-9f90-4cab-abc1-5407afe498df
28687840101OTC MONOGRAPH FINALAcino Products, Llc2014-04-01COCOA BUTTER, PHENYLEPHRINE HYDROCHLORIDERECTALSUPPOSITORYabfbc71b-40cc-43d1-85af-6a7ca7cc2a9b

spl(s)

#idtitlecategorytypelabelerlabeler actlast updateversionproduct(s)
100c4cf75-0be7-46bb-8855-1e2ec1dae8dd (view SPL)Safeway Inc. Hemorrhoidal Suppositories Drug FactsotcHuman OTCBetter Living Brands Llc2014-05-282211300160
20415c51b-5a12-49d4-8968-0131ddb85545 (view SPL)Dolgencorp, LLC Hemorrhoidal Suppositories Drug FactsotcHuman OTCDolgencorp, Llc2014-09-041559100279
313a7f88b-be9e-4cd8-89ed-169bddf7b041 (view SPL)SuperValu Inc. Hemorrhoidal Suppositories Drug FactsotcHuman OTCSupervalu, Inc2014-05-062411630557
41431397e-3515-4794-a494-70667948e14c (view SPL)Meijer Distribution, Inc. Hemorrhoidal Suppositories Drug FactsotcHuman OTCMeijer Distribution, Inc2014-10-141412500279
51435432d-5ff2-468b-808d-fb0c99a0717b (view SPL)HEB Hemorrhoidal Suppositories Drug FactsotcHuman OTCH-E-B2014-10-061378080279
61c704359-89a4-449c-961c-ad527cb467c2 (view SPL)Hemorrodil SupositoriosotcHuman OTCZurich Medical Labs, LlcMANUFACTURE2014-03-111613570135
71f6b907a-6bc3-4ef8-9973-d36339501686 (view SPL)Wal-Mart Hemorrhoidal Suppositories Drug FactsotcHuman OTCWalmart2012-10-101490350160
821744505-0fbc-4e74-bd8f-e1ae5e322f9f (view SPL)drug factsotcHuman OTCTarget Corpmanufacture2011-07-011116730395
9217c6442-f88f-4fb0-bda9-d585fc807aa6 (view SPL)Hemorrhoidal SuppositoriesotcHuman OTCAditya Labs Incmanufacture2014-09-263584010102
10379f8738-a871-4b09-abd1-c86386dfee04 (view SPL)Perrigo Hemorrhoidal Suppositories Drug FactsotcHuman OTCL. Perrigo Company2014-09-081001130279
1137db02e2-7710-4753-b90b-ffc690452644 (view SPL)DZA Brands, LLC Hemorrhoidal Suppositories Drug FactsotcHuman OTCDza Brands,2013-03-081553160160
123eb7905a-f6a0-47e7-b233-2f2a193c7706 (view SPL)Kmart Corporation Hemorrhoidal Suppositories Drug FactsotcHuman OTCKmart Corp2014-10-061497380279
133effe95a-2d1d-471e-a9e2-368bac232662 (view SPL)Family Dollar Services, Inc. Hemorrhoidal Suppositories Drug FactsotcHuman OTCFamily Dollar (Family Wellness)2013-03-051553190160
144583b50f-d864-41e1-803b-6ca44f6799d5 (view SPL)ShopRite Hemorrhoidal Suppositories Drug FactsotcHuman OTCWakefern Food Corporation2013-09-261411900160
1550f66c5a-7776-49d5-99cc-91e431682c55 (view SPL)Shopko Hemorrhoidal Suppositories Drug FactsotcHuman OTCShopko Stores Operating Co, Llc2013-08-211370120160
1652e27a92-93e4-4941-b1b3-9de03b5a39c6 (view SPL)Hemorrhoidal SuppositoriesotcHuman OTCGeritrex Corp2014-10-165541620045
1756a1ce72-8e54-4eb2-9c6e-eb479e7633a1 (view SPL)Safeway Inc. Hemorrhoidal Suppositories Drug FactsotcHuman OTCBetter Living Brands Llc2014-10-141211300279
1857a271a7-04f5-4c98-8259-894bbde7fbfb (view SPL)Hy-Vee, Inc. Hemorrhoidal Suppositories Drug FactsotcHuman OTCHy-Vee2013-03-251425070160
19581dd76f-d052-4448-8139-9a2e31891b25 (view SPL)Wal-Mart Hemorrhoidal Suppositories Drug FactsotcHuman OTCWalmart2014-09-082490350463
2068413266-83fd-4960-9380-10280c9afd44 (view SPL)American Sales Company Hemorrhoidal Suppositories Drug FactsotcHuman OTCFoodhold U.S.A., Llc2013-03-251415200160
216be1896d-f247-48d0-8a2f-f9b0d8e4a36e (view SPL)Dolgencorp, LLC Hemorrhoidal Suppositories Drug FactsotcHuman OTCDolgencorp, Llc2013-03-081559100160
226f85e72b-b323-4e1f-973c-5ced01564988 (view SPL)Perrigo Hemorrhoidal Suppositories Drug FactsotcHuman OTCL. Perrigo Company2013-03-251001130160
23714528a3-30d7-449b-8360-1587be91bb3d (view SPL)Western Family Hemorrhoidal Suppositories Drug FactsotcHuman OTCWestern Family2014-10-061553120279
2479aba427-9500-4689-a2a3-c8128eb08398 (view SPL)drug factsotcHuman OTCCvsmanufacture2011-07-012597790401
257f93a84b-d32f-4a12-9fe6-850bb09c6207 (view SPL)Rite Aid Corporation Hemorrhoidal Relief Suppositories Drug FactsotcHuman OTCRite Aid2013-03-251118220160
2681a3546b-5099-4b9a-b774-b3e79316b267 (view SPL)Topco Associates LLC. Hemorrhoidal Suppositories Drug FactsotcHuman OTCTop Care (Topco Associates Llc)2014-12-292368000279
278638a48e-9f90-4cab-abc1-5407afe498df (view SPL)otcHuman OTCChain Drug Consortium, Llcmanufacture2015-03-251680160321
2896df6b3d-9a71-42ee-b205-c70df5828cbc (view SPL)Kmart Corporation Hemorrhoidal Suppositories Drug FactsotcHuman OTCKmart Corp2013-09-101497380313
29970a6043-7302-4642-b33b-0f2502d85a24 (view SPL)Family Dollar Services, Inc. Hemorrhoidal Suppositories Drug FactsotcHuman OTCFamily Dollar (Family Wellness)2014-11-041553190279
30a01ee29d-02ca-4473-aa90-c2e8174dba26 (view SPL)otcHuman OTCQuality Choice (Chain Drug Marketing Association)manufacture2014-09-251638680208
31a23ded81-78ba-c199-a8f0-aaf360b216ff (view SPL)PREPARATION H HEMORRHOIDAL SUPPOSITORIESotcHuman OTCPfizer Consumer Healthcare2014-11-2410005732880, 005732883
32a241cb37-7007-4fd8-a12e-f3fc6d6f780e (view SPL)Publix Super Markets, Inc. Hemorrhoidal Suppositories Drug FactsotcHuman OTCPublix Super Markets, Inc2014-09-151560620279
33a8b1f7e9-78cf-4631-9375-938d5abb0fda (view SPL)Publix Super Markets, Inc. Hemorrhoidal Suppositories Drug FactsotcHuman OTCPublix Super Markets, Inc2013-03-051560620160
34aadcdc22-d47a-469d-bfb2-953c01dc13fa (view SPL)Shopko Hemorrhoidal Suppositories Drug FactsotcHuman OTCShopko Stores Operating Co, Llc2014-11-041370120279
35abfbc71b-40cc-43d1-85af-6a7ca7cc2a9b (view SPL)otcHuman OTCAcino Products, Llcmanufacture2014-06-231687840101
36bf1beca0-cc9b-4100-9db7-77f2d1e5497c (view SPL)Hy-Vee, Inc. Hemorrhoidal Suppositories Drug FactsotcHuman OTCHy-Vee2015-03-301425070279
37bff8f495-6007-4206-aaf3-7c08a0721b91 (view SPL)Meijer Distribution, Inc. Hemorrhoidal Suppositories Drug FactsotcHuman OTCMeijer Distribution, Inc2013-03-251412500330
38cfb1d1d9-d45d-4ead-bd73-48456dcff3df (view SPL)drug factsotcHuman OTCRite Aidmanufacture2011-07-011118220450
39d0fb0c36-dc29-455b-81fd-9b5792161f39 (view SPL)Walgreen Co. Hemorrhoidal Suppositories Drug FactsotcHuman OTCWalgreens2013-03-082003630160
40d29b7824-ff9e-4875-b3de-92721c8add0e (view SPL)SuperValu Inc. Hemorrhoidal Suppositories Drug FactsotcHuman OTCSupervalu, Inc2014-11-052411630279
41d44ca22a-dc20-454d-99aa-403a8c7a3e00 (view SPL)Kroger Co. Hemorrhoidal Suppositories Drug FactsotcHuman OTCKroger2014-09-041301420279
42d56ecdfd-5c77-41e0-a42c-d135d9f0a817 (view SPL)Target Corporation Hemorrhoidal Suppositories Drug FactsotcHuman OTCTarget Corp2015-04-142116730279
43ddafbdca-32c2-49c1-83d3-35b4155958c9 (view SPL)Rite Aid Corporation Hemorrhoidal Relief Suppositories Drug FactsotcHuman OTCRite Aid2015-01-141118220005
44e511d184-aedd-46f7-ab90-d7724766df73 (view SPL)Walgreen Co. Hemorrhoidal Suppositories Drug FactsotcHuman OTCWalgreens2014-09-301003630279
45e62b741c-1c1f-4bac-809a-3c315c12c276 (view SPL)HEB Hemorrhoidal Suppositories Drug FactsotcHuman OTCH-E-B2013-03-041378080160
46e74b71a1-915d-4e5b-b548-d5cce7945dbd (view SPL)Better Living Brands LLC Hemorrhoidal Suppositories Drug FactsotcHuman OTCBetter Living Brands Llc2015-11-051211300628
47e8a8431b-7851-4da0-a4fa-e242cf3daf2e (view SPL)CVS Pharmacy, Inc. Hemorrhoidal Suppositories Drug FactsotcHuman OTCCvs2015-07-232597790279
48ea5d26ad-2bfd-4178-857d-ce6b243cd760 (view SPL)American Sales Company Hemorrhoidal Suppositories Drug FactsotcHuman OTCFoodhold U.S.A., Llc2015-04-142415200004
49ea78ee9b-46c9-4c10-99e3-0b40652e659d (view SPL)DZA Brands, LLC Hemorrhoidal Suppositories Drug FactsotcHuman OTCDza Brands,2014-11-031553160279
50ecc0e2b3-3d48-4634-827b-24f5c0b7cfa1 (view SPL)Western Family Hemorrhoidal Suppositories Drug FactsotcHuman OTCWestern Family2013-02-241553120557

Data from: LOINC, MTHSPL, NDFRT, NCIT, RxNORM, UNII